Cholesteryl ester
transfer protein (CETP) is a member of the lipid transfer/lipopolysaccharide
binding protein gene family. CETP
transfers neutral lipids from high density lipoprotein (HDL)
to very low density lipoprotein (VLDL) and is present in
normal human plasma and serum. CETP plays a major role in
the catalism of HDL and, therefore, influences the
concentration, apolipoprotein content, and size of HDL
particles in plasma. Genetic deficiency in CETP results in a
variety of abnormalities in the concentration, composition
and function of high density and low density lipoproteins.
CETP deficiency is also associated with an increased risk
for colonary heart disease, despite a parallel increase in
HDL levels. The CETP Activity Assay Kit uses a donor
molecule containing a fluorescent neutral lipid that is
transferred to an acceptor molecule in the presence of CETP
from a given plasma and serum sample. The fluorescent
neutral lipid is present in a self-quenched state when
contained within the core of the donor molecule. CETP-mediated
transfer of the fluorescent neutral lipid to the acceptor
molecule results in an increase in fluorescence (Excitation:
465; Emission: 535).
Plasma phospholipid transfer protein (PLTP) is thought to
play a major role in the facilitated transfer of
phospholipids between lipoproteins and in the modulation of
high-density lipoprotein (HDL) particle size and
composition. PLTP-facilitated lipid transfer activity is
related to HDL and LDL metabolism, as well as lipoprotein
lipase activity, adiposity, and insulin resistance. The PLTP
Activity Assay Kit uses a donor molecule containing a
fluorescent self-quenched phospholipid that is transferred
to an acceptor molecule in the presence of PLTP. PLTP-mediated
transfer of the fluorescent phospholipid to the acceptor
molecule results in an increase in fluorescence (Excitation:
465 nm; Emission: 535 nm).
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